This is the first course of a three-course lecture and laboratory sequence for Biology majors, including Biology 21, 22, and 23. It describes how scientists approach the scientific method to generate scientific knowledge; studies the history, evidence, and mechanisms of evolution; identifies the chemistry of four classes of macromolecules; elucidates the cell principle including cell structure, function, and physiology; describes general energy metabolism; and illustrates the processes of growth and reproduction through mitosis, meiosis, development, and life cycles. Students are required to perform at least two experiments that require data collection, computer-based data management and graphing, and scientific analysis and interpretation of data. The course is designed to meet the needs of students transferring to upper division biology study.